How Canada’s Dr. Cameron Clokie Used BMP to Reconstruct Peter Russel’s Jaw

The medical field is ever-evolving courtesy of brilliant scientists such as Dr. Cameron Clokie. Read more: Bros Don’t Let Bros Have Bad Breath: Toronto Oral Surgeon Cameron Clokie Helps You Make a Good First Impression

Apart from being an accomplished oral and maxillofacial surgeon, Dr. Clokie is actively involved in research in a relatively new field of medicine known as regenerative medicine.

The success of the field will mean that reconstructive surgery will be a thing of the past. Although regenerative medicine is a huge arm of medicine, Dr. Clokie is concerned with using it to approach the musculoskeletal reconstruction process innovatively.

Dr. Clokie was once—for four years—an apprentice of Dr. Urist Marshall, the scientist who discovered bone morphogenetic protein (sometimes shortened to BMP). The protein located within the bone matrix of every human being is responsible for inducing bone growth.

Dr. Clokie uses BMP to initiate the growth of jaw bones in patients whose part(s) of the jaw is lacking either because of cancer or other factors that can damage the jowl area. Although Dr. Clokie started using regenerative medicine to reconstruct human mandibles in the late 90’s, Peter Russel’s case is perhaps the most publicized. Learn more about Cameron Clokie:

Dr. Clokie used BMP to assist Russel to regrow part of his jaw that the retired banker had lost to a benign tumor in 2003. At the time, Russel was among the first few patients—eight—to undergo a regenerative medicine procedure. Also, at the time, only two hospitals, Toronto General Hospital and Mount Sinai Hospital, administered the process.

Dr. Clokie’s procedure involved masking BMP out in a putty-like gel. The gel was then inserted into Russel’s jaw specifically where a gap existed. This was followed by strategically using a titanium rod to hold the gel in place. What followed after 120 hours is a growth of blood vessels over the gel structure.

BMP is a peculiar compound; for example, it liquefies at low temperatures and solidifies at higher temperatures. It is no surprise that when blood vessels started growing over the gel, it dissolved allowing room for Russel’s jawbone to regrow and fill the gap.

Apparently, there is a risk of uncontrolled bone growth, but Russel was ready to take a gamble. However, it turned out well for Russel.

Read more: Cameron Clokie Believes Technology is Changing Dentistry For The Better

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